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Article

Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells.

Investigative ophthalmology & visual science - 7 Jan 2013

Gnana-Prakasam Jaya P, Veeranan-Karmegam Rajalakshmi, Coothankandaswamy Veena, Reddy Sushma K, Martin Pamela M, Thangaraju Muthusamy, Smith Sylvia B, Ganapathy Vadivel

Abstract excerpt

PURPOSE: Hemochromatosis is a disorder of iron overload arising mostly from mutations in HFE. HFE is expressed in retinal pigment epithelium (RPE), and Hfe(-/-) mice develop age-related iron accumulation and retinal degeneration associated with RPE hyperproliferation. Here, the mechanism underlying the hyperproliferative phenotype in RPE was investigated. METHODS: Cellular senescence was monitored by...

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Identifiers

PMID: 23169885
DOI: 10.1167/iovs.12-10312
PMCID: PMC3544423

Genes

RPE
HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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