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Article

Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin

20 Jul 2022

Abstract excerpt

Cellular senescence of the retinal pigment epithelium (RPE) is thought to play an important role in vision-threatening retinal degenerative diseases, such as age-related macular degeneration (AMD). However, the single-cell RNA profiles of control RPE tissue and RPE tissue exhibiting cellular senescence are not well known. We have analyzed the single-cell transcriptomes of control mice and mice with low-dose...

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PMID: 35859009
DOI: 10.1038/s42003-022-03676-3

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