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Article

ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

18 Dec 2011

Abstract excerpt

We demonstrate that a Rho kinase inhibitor (Y-27632), in combination with fibroblast feeder cells, induces normal and tumor epithelial cells from many tissues to proliferate indefinitely in vitro, without transduction of exogenous viral or cellular genes. Primary prostate and mammary cells, for example, are reprogrammed toward a basaloid, stem-like phenotype and form well-organized prostaspheres and mammospheres...

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PMID: 22189618
DOI: 10.1016/j.ajpath.2011.10.036

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