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Y-27632 acts beyond ROCK inhibition to maintain epidermal stem-like cells in culture

10 Aug 2023

Abstract excerpt

Conditional reprogramming is a cell culture technique that effectively immortalizes epithelial cells with normal genotypes by renewing epidermal stem cells. Y-27632, a compound that promotes conditional reprogramming through an unknown mechanism, was developed to inhibit the two Rho-associated kinase (ROCK) isoforms. We used human foreskin keratinocytes (HFKs) to study the role of Y-27632 in conditional...

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PMID: 37698512
DOI: 10.1242/jcs.260990

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