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Article

Will kinase inhibitors make it as glioblastoma drugs?

Current topics in microbiology and immunology - 1 Jan 2012

Mellinghoff Ingo K, Schultz Nikolaus, Mischel Paul S, Cloughesy Timothy F

Abstract excerpt

Kinase inhibitors have emerged as effective cancer therapeutics in a variety of human cancers. Glioblastoma (GBM), the most common malignant brain tumor in adults, represents a compelling disease for kinase inhibitor therapy because the majority of these tumors harbor genetic alterations that result in aberrant activation of growth factor signaling pathways. Attempts to target the Ras-Phosphatidylinositol...

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Identifiers

PMID: 22015553
DOI: 10.1007/82_2011_178
PMCID: PMC3784987

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