Article
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
Autophagy - 1 Oct 2010
Geisler Sven, Holmström Kira M, Treis Angela, Skujat Diana, Weber Stephanie S, Fiesel Fabienne C, Kahle Philipp J, Springer Wolfdieter
Abstract excerpt
Mitochondrial dysfunction is an early sign of many neurodegenerative diseases. Very recently, two Parkinson disease (PD) associated genes, PINK1 and Parkin, were shown to mediate the degradation of damaged mitochondria via selective autophagy (mitophagy). PINK1 kinase activity is needed for prompt and efficient Parkin recruitment to impaired mitochondria. PD-associated Parkin mutations interfere with the process...
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