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Article

Methylation status of genes flanking the fragile site in males with the fragile-X syndrome: a test of the imprinting hypothesis.

American journal of human genetics - 1 Apr 1990

Khalifa M M, Reiss A L, Migeon B R

Abstract excerpt

Laird has suggested that the mutation responsible for the fragile X (FraX) syndrome interferes with the process of X chromosome reactivation in oocytes, thus blocking the transcription of loci at or neighboring the fragile site (Xq27.3) and producing the clinical FraX phenotype; he has also suggested that the transcriptional block might result from inappropriate DNA methylation. We have explored the latter...

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Identifiers

PMID: 2316521
PMCID: PMC1683650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation status of genes flanking the fragile site in males with the fragile-X syndrome: a test of the imprinting hypothesis.PMID 2316521Read ↗

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