Fragile X gene instability: anchoring AGGs and linked microsatellites.

Article

Fragile X gene instability: anchoring AGGs and linked microsatellites.

American journal of human genetics - 1 Aug 1995

Zhong N, Yang W, Dobkin C, Brown W T

Abstract excerpt

Interspersed AGGs within the FMR1 gene CGG repeat region may anchor the sequence and prevent slippage during replication. In order to detect the AGG position variations, we developed a method employing partial MnlI restriction analysis and analyzed X chromosomes from 187 males, including 133 norm...

Topics

Alleles
Base Sequence
DNA, Satellite
Fragile X Syndrome
Genetic Linkage
Haplotypes
Humans
Male
Molecular Sequence Data
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.