Article
Sex difference in methylation of single-copy genes in human meiotic germ cells: implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations.
Somatic cell and molecular genetics - 1 May 1990
Driscoll D J, Migeon B R
Abstract excerpt
To determine the methylation status of female germ cells in reference to the programmed reversal of X chromosome inactivation in these cells, we examined human fetal ovaries at developmental stages from the time germ cells initiate meiosis to when they cease to synthesize DNA (8-21 weeks gestatio...
Topics
- Blotting, Southern
- Cells, Cultured
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Dinucleoside Phosphates
- Dosage Compensation, Genetic
- Female
- Genes
- Gestational Age
- Humans
- Male
- Meiosis
- Methylation
- Mutation
- Ovary
- Ovum
- Sex Characteristics
- Spermatozoa