The hypervariable DXS255 locus contains a LINE-1 repetitive element with a CpG island that is extensively methylated only on the active X chromosome.

doi:10.1016/s0888-7543(05)80157-0

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Article

The hypervariable DXS255 locus contains a LINE-1 repetitive element with a CpG island that is extensively methylated only on the active X chromosome.

Genomics - 1 Nov 1992

Hendriks R W, Hinds H, Chen Z Y, Craig I W

Abstract excerpt

The DXS255 locus at Xp11.22 is highly polymorphic due to a 26-bp variable number of tandem repeats (VNTR) motif. In previous studies, one of the MspI sites flanking the VNTR manifested a correlation between methylation and X chromosome inactivation. Here we show, by DNA sequence analysis, that th...

Topics

Base Sequence
Blotting, Southern
DNA
Deoxyribonuclease HpaII
Deoxyribonucleases, Type II Site-Specific
Dinucleoside Phosphates
Dosage Compensation, Genetic
Female
Genetic Variation
Humans
Male
Methylation
Molecular Sequence Data
Repetitive Sequences, Nucleic Acid
Restriction Mapping
Tumor Cells, Cultured
X Chromosome

Source

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Identifiers

PMID: 1385307
DOI: 10.1016/s0888-7543(05)80157-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1385307-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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