Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP).

British journal of haematology - 1 Jan 2013

Basciano Paul A, Bussel James, Hafeez Zeeshan, Christos Paul J, Giannakakou Paraskevi

Abstract excerpt

Predictive biomarkers are needed in immune thrombocytopenia (ITP). Single nucleotide polymorphisms (SNPs) in beta 1 tubulin are potential candidates, as beta 1 tubulin is integral for platelet production and function, and SNPs in beta 1 tubulin have been associated with distinct phenotypes in platelets. We investigated the most prevalent beta 1 tubulin SNP (R307H) as a biomarker in patients with ITP via a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Murine-Derived
Share to Benzoates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrazines

Share to Purpura, Thrombocytopenic, Idiopathic

Share to Receptors, Fc

Share to Thiophenes

Share to Thrombopoiesis

Share to Thrombopoietin

Source

Open in PubMed Open full text

Identifiers

PMID: 23157319
DOI: 10.1111/bjh.12124
PMCID: PMC4001250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP).PMID 23157319Read ↗

β-1 tubulin R307H SNP alters microtubule dynamics and affects severity of a hereditary thrombocytopenia.Semantic proximity Read ↗

Deciphering the genetic basis of immune thrombocytopenia: current evidence for genetic predisposition in adult ITP.Semantic proximity Read ↗

Disease pathogenesis, treatment effectiveness, and co-morbid burden among adult patients with primary immune thrombocytopenia (ITP)Semantic proximity Read ↗

Expanding the genetic spectrum of TUBB1 -related thrombocytopeniaSemantic proximity Read ↗

Hematologic β-tubulin VI isoform exhibits genetic variability that influences paclitaxel toxicity.Semantic proximity Read ↗

The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure.Semantic proximity Read ↗

HDAC3 single-nucleotide polymorphism rs2530223 is associated with increased susceptibility and severity of primary immune thrombocytopenia.Semantic proximity Read ↗

Association between gene polymorphisms and clinical features in idiopathic thrombocytopenic purpura patients.Semantic proximity Read ↗

Mutations in the most divergent α-tubulin isotype, α8-tubulin, cause defective platelet biogenesis.Semantic proximity Read ↗

Platelet-associated antibodies, cellular immunity and FCGR3a genotype influence the response to rituximab in immune thrombocytopenia.Semantic proximity Read ↗

Stromal cell-derived factor-1 rs2297630 polymorphism associated with platelet production and treatment response in Chinese patients with chronic immune thrombocytopenia.Semantic proximity Read ↗

Association of polymorphisms in human platelet antigens with idiopathic thrombocytopenic purpura in Macedonians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.