Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Platelet-associated antibodies, cellular immunity and FCGR3a genotype influence the response to rituximab in immune thrombocytopenia.

British journal of haematology - 1 Aug 2012

Cooper Nichola, Stasi Roberto, Cunningham-Rundles Susanna, Cesarman Ethel, McFarland Janice G, Bussel James B

Abstract excerpt

Rituximab is widely used in autoimmune diseases including immune thrombocytopenia (ITP), although the mechanism of effect remains unclear. This study describes the effects of rituximab on platelet-associated antibodies (PA-APAs), B and T cell counts and clonality ( IGHV and TRG@ gene rearrangements), FCGR3A (FcγRIIIa) and FCGR2A (FcγRIIa) polymorphisms and correlation to anti-CD40 ligand (CD40L) response. PA-APA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Murine-Derived
Share to Antigens, CD20

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD40 Ligand

Share to Immunity, Cellular

Share to Leukocyte Count

Share to Purpura, Thrombocytopenic, Idiopathic

Share to Rituximab

Share to Thrombopoietin

Source

Identifiers

PMID: 22775462
DOI: 10.1111/j.1365-2141.2012.09184.x

Genes

TRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Platelet-associated antibodies, cellular immunity and FCGR3a genotype influence the response to rituximab in immune thrombocytopenia.PMID 22775462Read ↗

The impact of Fc gamma receptor IIa and IIIa gene polymorphisms on the therapeutic response of rituximab in Egyptian adult immune thrombocytopenic purpura.Semantic proximity Read ↗

A distinct plasmablast and naïve B-cell phenotype in primary immune thrombocytopenia.Semantic proximity Read ↗

Comprehensive genetic and functional analysis of FcγRs in rituximab therapy for autoimmunity reveals a key role for FcγRIIIa on NK cellsSemantic proximity Read ↗

FC gamma receptor polymorphisms in patients with immune thrombocytopenia.Semantic proximity Read ↗

Association between gene polymorphisms and clinical features in idiopathic thrombocytopenic purpura patients.Semantic proximity Read ↗

[Pathophysiology of immune thrombocytopenia].Semantic proximity Read ↗

The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus.Semantic proximity Read ↗

Pathogenesis in immune thrombocytopenia: new insights.Semantic proximity Read ↗

CD4+ T cell phenotypes in the pathogenesis of immune thrombocytopenia.Semantic proximity Read ↗

Immune thrombocytopenia: A review of upfront treatment strategies.Semantic proximity Read ↗

[Polymorphisms of FcγRIIA, FcγRIIIA and FcγRIIB in patients with immune thrombocytopenia and their clinical significance].Semantic proximity Read ↗

Comprehensive genetic and functional analyses of Fc gamma receptors influence on response to rituximab therapy for autoimmunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.