Article
Genetic overlap between apparently sporadic motor neuron diseases.
PloS one - 1 Jan 2012
van Blitterswijk Marka, Vlam Lotte, van Es Michael A, van der Pol W-Ludo, Hennekam Eric A M, Dooijes Dennis, Schelhaas Helenius J, van der Kooi Anneke J, de Visser Marianne, Veldink Jan H, van den Berg Leonard H
Abstract excerpt
Progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS) are devastating motor neuron diseases (MNDs), which result in muscle weakness and/or spasticity. We compared mutation frequencies in genes known to be associated with MNDs between patients with apparently sporadic PMA and ALS. A total of 261 patients with adult-onset sporadic PMA, patients with sporadic ALS, and control subjects of Dutch...
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