Article
Evidence for an oligogenic basis of amyotrophic lateral sclerosis.
Human molecular genetics - 1 Sept 2012
van Blitterswijk Marka, van Es Michael A, Hennekam Eric A M, Dooijes Dennis, van Rheenen Wouter, Medic Jelena, Bourque Pierre R, Schelhaas Helenius J, van der Kooi Anneke J, de Visser Marianne, de Bakker Paul I W, Veldink Jan H, van den Berg Leonard H
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a substantial heritable component. In pedigrees affected by its familial form, incomplete penetrance is often observed. We hypothesized that this could be caused by a complex inheritance of risk variants in multiple genes. Therefore, we screened 111 familial ALS (FALS) patients from 97 families, and large cohorts of sporadic ALS (SALS)...
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