Absence of angiogenic genes modification in Italian ALS patients.

doi:10.1016/j.neurobiolaging.2006.10.008

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Article

Absence of angiogenic genes modification in Italian ALS patients.

Neurobiology of aging - 1 Feb 2008

Del Bo Roberto, Scarlato Marina, Ghezzi Serena, Martinelli-Boneschi Filippo, Corti Stefania, Locatelli Federica, Santoro Domenico, Prelle Alessandro, Briani Chiara, Nardini Martina, Siciliano Gabriele, Mancuso Michelangelo, Murri Luigi, Bresolin Nereo, Comi Giacomo Pietro

Abstract excerpt

To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic determinants in the susceptibility to sporadic ALS in Italian patients. VEGF genotype and haplotype analysis revealed no association between any variants and the risk of ALS. Regarding ANG gene, no mutation was detected and the rs11701 polymorphism, previously described as associated with ALS, was not differently...

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PMID: 17113198
DOI: 10.1016/j.neurobiolaging.2006.10.008

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