Article
Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis.
Annals of neurology - 1 Dec 2011
van Es Michael A, Schelhaas Helenius J, van Vught Paul W J, Ticozzi Nicola, Andersen Peter M, Groen Ewout J N, Schulte Claudia, Blauw Hylke M, Koppers Max, Diekstra Frank P, Fumoto Katsumi, LeClerc Ashley Lyn, Keagle Pamela, Bloem Bastiaan R, Scheffer Hans, van Nuenen Bart F L, van Blitterswijk Marka, van Rheenen Wouter, Wills Anne-Marie, Lowe Patrick P, Hu Guo-fu, Yu Wenhao, Kishikawa Hiroko, Wu David, Folkerth Rebecca D, Mariani Claudio, Goldwurm Stefano, Pezzoli Gianni, Van Damme Philip, Lemmens Robin, Dahlberg Caroline, Birve Anna, Fernández-Santiago Rubén, Waibel Stefan, Klein Christine, Weber Markus, van der Kooi Anneke J, de Visser Marianne, Verbaan Dagmar, van Hilten Jacobus J, Heutink Peter, Hennekam Eric A M, Cuppen Edwin, Berg Daniela, Brown Robert H, Silani Vincenzo, Gasser Thomas, Ludolph Albert C, Robberecht Wim, Ophoff Roel A, Veldink Jan H, Pasterkamp R Jeroen, de Bakker Paul I W, Landers John E, van de Warrenburg Bart P, van den Berg Leonard H
Abstract excerpt
OBJECTIVE: Several studies have suggested an increased frequency of variants in the gene encoding angiogenin (ANG) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, a few ALS patients carrying ANG variants also showed signs of Parkinson disease (PD). Furthermore, relatives of ALS patients have an increased risk to develop PD, and the prevalence of concomitant motor neuron disease in PD is...
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