Article
Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis.
Neurogenetics - 1 Feb 2008
Gellera Cinzia, Colombrita Claudia, Ticozzi Nicola, Castellotti Barbara, Bragato Cinzia, Ratti Antonia, Taroni Franco, Silani Vincenzo
Abstract excerpt
Angiogenin (ANG) gene, coding for an angiogenic factor up-regulated by hypoxia and expressed in ventral horn motor neurons, is a novel candidate for the pathogenesis of amyotrophic lateral sclerosis (ALS). ALS is a fatal neurodegenerative disease characterized by the selective loss of cortical and spinal motor neurons. Missense mutations in ANG gene have been identified in two ALS populations from Northern Europe...
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