Article
Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis.
Archives of neurology - 1 Oct 2008
Paubel Agathe, Violette Jeremy, Amy Maïté, Praline Julien, Meininger Vincent, Camu William, Corcia Philippe, Andres Christian R, Vourc'h Patrick
Abstract excerpt
BACKGROUND: Mutations in the angiogenin gene, ANG, have been associated recently with familial and sporadic forms of amyotrophic lateral sclerosis (ALS). However, the cellular and molecular mechanisms that link ANG, a multidomain protein, to ALS are still unknown. OBJECTIVE: To assess the frequency of ANG gene mutations in 855 French patients with sporadic ALS. DESIGN: We analyzed by direct sequencing the full...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.