Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells.

Cancer discovery - 1 Feb 2013

Ding Yu, Hubert Christopher G, Herman Jacob, Corrin Philip, Toledo Chad M, Skutt-Kakaria Kyobi, Vazquez Julio, Basom Ryan, Zhang Bin, Risler Jennifer K, Pollard Steven M, Nam Do-Hyun, Delrow Jeffery J, Zhu Jun, Lee Jeongwu, DeLuca Jennifer, Olson James M, Paddison Patrick J

Abstract excerpt

UNLABELLED: To identify new candidate therapeutic targets for glioblastoma multiforme, we combined functional genetics and glioblastoma network modeling to identify kinases required for the growth of patient-derived brain tumor-initiating cells (BTIC) but that are dispensable to proliferating human neural stem cells (NSC). This approach yielded BUB1B/BUBR1, a critical mitotic spindle checkpoint player, as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetochores

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Neural Stem Cells

Share to Spindle Apparatus

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 23154965
DOI: 10.1158/2159-8290.CD-12-0353
PMCID: PMC3632446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells.PMID 23154965Read ↗

Sensitivity to BUB1B Inhibition Defines an Alternative Classification of GlioblastomaSemantic proximity Read ↗

FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancersSemantic proximity Read ↗

<i>FBXO42</i> activity is required to prevent mitotic arrest, spindle assembly checkpoint activation, and lethality in glioblastoma and other cancersSemantic proximity Read ↗

Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastomaSemantic proximity Read ↗

The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastomaSemantic proximity Read ↗

The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene ExpressionSemantic proximity Read ↗

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets.Semantic proximity Read ↗

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastomaSemantic proximity Read ↗

A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in GlioblastomaSemantic proximity Read ↗

Repression of Aurora kinase B prevents growth and tissue invasion in medulloblastomaSemantic proximity Read ↗

Expression of the checkpoint kinase BUB1 is a predictor of response to cancer therapiesSemantic proximity Read ↗

Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.