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Structure of Human Pro-Matrix Metalloproteinase-2: Activation Mechanism Revealed

4 Jun 1999

Abstract excerpt

Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide...

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PMID: 10356396
DOI: 10.1126/science.284.5420.1667

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