Article
Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: a Hellenic Cooperative Oncology Group study.
Pharmacogenomics - 1 Nov 2012
Nikitas Nikitas, Karadimou Alexandra, Tsitoura Eliza, Soupos Nikolaos, Tsiatas Marinos, Karavasilis Vasilios, Pectasides Dimitrios, Pavlidis Nikolaos, Chrisofos Michael, Adamakis Ioannis, Murray Samuel, Fountzilas Georgios, Dimopoulos Meleios-Athanasios, Bamias Aristotle
Abstract excerpt
AIM: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined. MATERIALS & METHODS: Genotyping of 19007C>T and 8092C>A polymorphisms was determined by PCR amplification and RFLP in 113 advanced UC patients, treated with platinum-based chemotherapy. RESULTS: Seventy eight patients (69%) were carriers of...
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