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Article

ERCC1 SNPs as Potential Predictive Biomarkers in Non-Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy.

Cancer investigation - 1 Apr 2015

Kalikaki Aristea, Voutsina Alexandra, Koutsopoulos Anastasios, Papadaki Chara, Sfakianaki Maria, Yachnakis Emmanouel, Xyrafas Alexandros, Kotsakis Athanasios, Agelaki Sofia, Souglakos John, Mavroudis Dimitrios, Georgoulias Vassilis

Abstract excerpt

Polymorphisms in ERCC1, XPD, and XRCC1 were examined for (a) association with the clinical outcome of 107 non-small cell lung cancer patients receiving front-line platinum-based chemotherapy, and (b) correlation with the ERCC1 mRNA levels of 176 chemo-naive primary tumors. The ERCC1-C8092 allele and the number of ERCC1 polymorphic variants (C8092A and Asn118Asn) were associated with progression-free survival. In...

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Identifiers

PMID: 25647444
DOI: 10.3109/07357907.2014.1001897

Genes

ERCC1
XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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