Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in the SLC19A1 gene and methotrexate toxicity in rheumatoid arthritis patients.

Pharmacogenomics - 1 Nov 2012

Bohanec Grabar Petra, Leandro-García Luis J, Inglada-Pérez Lucía, Logar Dušan, Rodríguez-Antona Cristina, Dolžan Vita

Abstract excerpt

AIM: We investigated the clinical relevance of SLC19A1 genetic variability for methotrexate (MTX) toxicity in rheumatoid arthritis patients using a haplotype-based approach. PATIENTS & METHODS: Two hundred and twelve unrelated rheumatoid arthritis patients and 89 lymphoblastoid cell lines were used to investigate the effect of SLC19A1 SNPs and haplotypes on MTX adverse events and treatment discontinuation....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Pharmacological

Share to Cell Line

Share to Genetic Association Studies

Share to Linkage Disequilibrium

Share to Methotrexate

Share to Reduced Folate Carrier Protein

Source

Identifiers

PMID: 23148635
DOI: 10.2217/pgs.12.150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the SLC19A1 gene and methotrexate toxicity in rheumatoid arthritis patients.PMID 23148635Read ↗

SLC19A1, SLC46A1 and SLCO1B1 polymorphisms as predictors of methotrexate-related toxicity in Portuguese rheumatoid arthritis patients.Semantic proximity Read ↗

Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients.Semantic proximity Read ↗

SLC04A1, SLC22A2 and SLC28A2 variants not related to methotrexate efficacy or toxicity in rheumatoid arthritis patients.Semantic proximity Read ↗

SLCO1B1 variants as predictors of methotrexate-related toxicity in children with juvenile idiopathic arthritis.Semantic proximity Read ↗

Pharmacogenetic insights into MTHFR and SLC19A1 variants in low-dose methotrexate therapy for rheumatologic diseases.Semantic proximity Read ↗

Clinical-pharmacogenetic predictive models for MTX discontinuation due to adverse events in rheumatoid arthritis.Semantic proximity Read ↗

Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.Semantic proximity Read ↗

The association between methotrexate metabolism-related gene polymorphisms and therapeutic efficacy and toxicity in patients with rheumatoid arthritis.Semantic proximity Read ↗

Relationship Between Polymorphisms in Methotrexate Pathway Genes and Outcome of Methotrexate Treatment in a Cohort of 119 Patients with Juvenile Idiopathic Arthritis.Semantic proximity Read ↗

The C677T polymorphism in the MTHFR gene is associated with the toxicity of methotrexate in a Spanish rheumatoid arthritis population.Semantic proximity Read ↗

Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis.Semantic proximity Read ↗

Using pharmacogenetics to predict methotrexate response in rheumatoid arthritis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.