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Article

Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy

26 Apr 2012

Abstract excerpt

OBJECTIVES: Bcl-2 is a protein that inhibits apoptosis, leading to cell survival. The Bcl-2 family has six different anti-apoptotic proteins, three pro-apoptotic proteins that are similar in structure, and other integrating proteins that function as promotors or inhibitors in the progression of apoptosis. In this discussion paper, we provide an overview of apoptosis, the role of Bcl-2 in normal cellular and...

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PMID: 23146031
DOI: 10.1111/j.2042-7158.2012.01526.x

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