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Article

Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats.

American journal of physiology. Heart and circulatory physiology - 15 Jan 2013

Pabbidi Mallikarjuna R, Juncos Julio, Juncos Luis, Renic Marija, Tullos Hurtis J, Lazar Jozeph, Jacob Howard J, Harder David R, Roman Richard J

Abstract excerpt

This study examined the effects of transfer of a 2.4-Mbp region of rat chromosome 1 (RNO1) from Brown Norway (BN) into fawn-hooded hypertensive (FHH) rats on autoregulation (AR) of cerebral blood flow (CBF) and the myogenic response of middle cerebral arteries (MCAs). AR of CBF was poor in FHH and FHH.1(BN) AR(-) congenic strains that excluded the critical 2.4-Mbp region. In contrast, AR was restored in FHH.1(BN)...

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Source

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Identifiers

PMID: 23144316
DOI: 10.1152/ajpheart.00622.2012
PMCID: PMC3543673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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