Article
Association between newly identified variant form of DNA polymerase beta (Δ 208-304) and ovarian cancer.
Cancer biomarkers : section A of Disease markers - 1 Jan 2012
Khanra Kalyani, Panda Kakali, Bhattacharya Chandan, Mitra Ak, Sarkar Ranu, Banerjee Sipra, Bhattacharyya Nandan
Abstract excerpt
BACKGROUND: Base excision repair (BER) is a key pathway for maintaining genomic stability. A key enzyme in the BER pathway is DNA polymerase beta (polβ), which removes the deoxyribose phosphate group (dRP) and fills in the gap with a nucleotide after the DNA lesion is excised. It has been shown that more than thirty percent of breast, bladder, esophageal, colon, and gastric cancer samples studied so far have...
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