Article
Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Apr 2013
Liang Xu, Zhang Jie, Zhu Yulin, Lu Yuanli, Zhou Xinna, Wang Zheng, Yu Jing, Yan Ying, Di Lijun, Che Li, Jiang Hanfang, Shao Bin, Wang Xiaoli, Yang Huabing, Lyerly Herbert Kim, Ren Jun
Abstract excerpt
AIM: This study was designed to explore the genetic polymorphism of IL-10 (-1082A/G, -592A/C, -819T/C), TNF-α (-308G/A) with susceptibility to docetaxel-induced liver injury (DILI) in Chinese breast cancer patients. METHODS: The targeted genetic polymorphisms of IL10-1082G/A, IL10-592A/C, IL10-819T/C, TNF-308G/A from 40 patients with DILI were assayed by matrix-assisted laser desorption/ionization-time of flight...
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