Article
Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population.
Journal of clinical laboratory analysis - 1 Nov 2012
Zhan Xiaoying, Wu Wenting, Han Baohui, Gao Ge, Qiao Rong, Lv Juan, Zhang Shuyu, Zhang Wei, Fan Weiwei, Chen Hongyan, Zhang Tianbao, Gu Aiqin, Shen Jie, Wu Qihan, Lu Daru
Abstract excerpt
BACKGROUND: Rs11614913 is a polymorphism in hsa-miR-196a2 reported to alter mature microRNA expression and function. This single-nucleotide polymorphism (SNP) was reported to be associated with susceptibility and prognosis of lung cancer. METHODS: In this article, association study was performed to reveal the relation between SNP and response rate or severe toxicity after platinum-based regimen in advanced...
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