Article
Hsa-miR-196a2 functional SNP is associated with the risk of ESCC in individuals under 60 years old.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Feb 2014
Wang Na, Li Yan, Zhou Rong-Miao, Wang Gui-Ying, Wang Chun-Mei, Chen Zhi-Feng, Liu Wei
Abstract excerpt
BACKGROUND AND AIM: The miR-196a2 gene contains a C/T polymorphism (rs11614913). Its presence could change the conformation of secondary structure of miR-196a2 RNA, and directly affect the binding to target mRNAs and the miRNA maturation process. Both of which eventually alter protein expression and contributed to cancer susceptibility. This study assessed whether the rs11614913 single nucleotide polymorphism...
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