Article
Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas.
Cancer science - 1 Sept 2017
Matsubara Daisuke, Soda Manabu, Yoshimoto Taichiro, Amano Yusuke, Sakuma Yuji, Yamato Azusa, Ueno Toshihide, Kojima Shinya, Shibano Tomoki, Hosono Yasuyuki, Kawazu Masahito, Yamashita Yoshihiro, Endo Shunsuke, Hagiwara Koichi, Fukayama Masashi, Takahashi Takashi, Mano Hiroyuki, Niki Toshiro
Abstract excerpt
The major driver mutations of lung cancer, EGFR mutations and EML4-ALK fusion, are mainly detected in terminal respiratory unit (TRU)-type lung adenocarcinomas, which typically show lepidic and/or papillary patterns, but are rarely associated with a solid or invasive mucinous morphology. In order...
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