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Article

Purification, crystallization and preliminary crystallographic analysis of human cystathionine β-synthase.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Nov 2012

Oyenarte Iker, Majtan Tomas, Ereño June, Corral-Rodríguez María Angeles, Kraus Jan P, Martínez-Cruz Luis Alfonso

Abstract excerpt

Human cystathionine β-synthase (CBS) is a pyridoxal-5'-phosphate-dependent hemeprotein, whose catalytic activity is regulated by S-adenosylmethionine. CBS catalyzes the β-replacement reaction of homocysteine (Hcy) with serine to yield cystathionine. CBS is a key regulator of plasma levels of the thrombogenic Hcy and deficiency in CBS is the single most common cause of homocystinuria, an inherited metabolic...

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Identifiers

PMID: 23143240
DOI: 10.1107/S1744309112037219
PMCID: PMC3515372

Genes

CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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