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Article

Disease-causing cystathionine β-synthase linker mutations impair allosteric regulation.

The Journal of biological chemistry - 1 Dec 2023

Roman Joseph V, Mascarenhas Romila, Ceric Karanfil, Ballou David P, Banerjee Ruma

Abstract excerpt

Cystathionine β-synthase (CBS) catalyzes the committing step in the transsulfuration pathway, which is important for clearing homocysteine and furnishing cysteine. The transsulfuration pathway also generates H2S, a signaling molecule. CBS is a modular protein with a heme and pyridoxal phosphate-binding catalytic core, which is separated by a linker region from the C-terminal regulatory domain that binds...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37949228
DOI: 10.1016/j.jbc.2023.105449
PMCID: PMC10746528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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