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Deletion Mutagenesis of Human Cystathionine β-Synthase

1 Dec 2002

Abstract excerpt

Cystathionine beta-synthase is a tetrameric hemeprotein that catalyzes the pyridoxal 5'-phosphate-dependent condensation of serine and homocysteine to cystathionine. We have used deletion mutagenesis of both the N and C termini to investigate the functional organization of the catalytic and regulatory regions of this enzyme. Western blot analysis of these mutants expressed in Escherichia coli indicated that...

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PMID: 12379655
DOI: 10.1074/jbc.m207087200

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