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Article

A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.

5 Jul 1994

Abstract excerpt

Human cystathionine beta-synthase (CBS; EC 4.2.1.22) deficiency results in a recessive genetic disorder whose clinical and biochemical manifestations vary greatly among affected individuals. In an effort to identify and analyze mutations in the human CBS gene, we have developed a yeast expression system for human CBS. We have cloned and sequenced a human cDNA that codes for CBS and have expressed the human CBS...

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PMID: 8022826
DOI: 10.1073/pnas.91.14.6614

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