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Article

Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis.

Human immunology - 1 Feb 2013

Morita Susumu, Joshita Satoru, Umemura Takeji, Katsuyama Yoshihiko, Kimura Takefumi, Komatsu Michiharu, Matsumoto Akihiro, Yoshizawa Kaname, Kamijo Astushi, Yamamura Nobuyoshi, Tanaka Eiji, Ota Masao

Abstract excerpt

Primary biliary cirrhosis (PBC) is characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often result in liver failure. Toll-like receptor (TLR) 4 recognizes lipopolysaccharides of Gram-negative bacteria. Infectious agents have been suspected to play a crucial role in PBC pathogenesis since TLR4 expression was found in bile duct epithelial cells and periportal...

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Source

Identifiers

PMID: 23142582
DOI: 10.1016/j.humimm.2012.10.022

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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