Article
Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2013
Powell Timothy R, Schalkwyk Leonard C, Heffernan Andrew L, Breen Gerome, Lawrence Timothy, Price Tom, Farmer Anne E, Aitchison Katherine J, Craig Ian W, Danese Andrea, Lewis Cathryn, McGuffin Peter, Uher Rudolf, Tansey Katherine E, D'Souza Ursula M
Abstract excerpt
Converging evidence suggests that the activation of the inflammatory cytokine pathway is important in the pathophysiology of unipolar depression. Antidepressants have anti-inflammatory properties and evidence suggests that inter-individual variability in response to antidepressants may reflect genetic differences in the inflammatory cytokine pathway. In particular, protein levels of Tumor Necrosis Factor (TNF)...
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