Article
Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells.
Human gene therapy - 1 Jan 2013
Pelascini Laetitia P L, Janssen Josephine M, Gonçalves Manuel A F V
Abstract excerpt
Integration-defective lentiviral vectors (IDLVs) are being increasingly deployed in both basic and preclinical gene transfer settings. Often, however, the IDLV transgene expression profile is muted when compared to that of their integration-proficient counterparts. We hypothesized that the episom...
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