Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene Therapy

15 Jan 2025

Abstract excerpt

Gamma-Retroviral (RVVs) and lentiviral vectors (LVVs) represent indispensable tools in somatic gene therapy, mediating the efficient, stable transfer of therapeutic genes into a variety of human target cells. LVVs, in contrast to RVVs, are capable of stably genetically modifying non-proliferating target cells, making them the superior instrument in cell and gene therapy. To date, the LVV manufacturing process...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Ethics and Regulation
Share to CRISPR and Genetic Engineering
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39812051
DOI: 10.2174/0115665232332412241118063211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene TherapyPMID 39812051Read ↗

Production of lentiviral vectorsSemantic proximity Read ↗

Lentiviral vector packaging and producer cell lines yield titers equivalent to the industry-standard four-plasmid processSemantic proximity Read ↗

Generation of stable suspension producer cell lines for serum‐free lentivirus productionSemantic proximity Read ↗

Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell LinesSemantic proximity Read ↗

Construction of stable packaging cell lines for clinical lentiviral vector productionSemantic proximity Read ↗

Establishment and Characterization of a Stable Producer Cell Line Generation Platform for the Manufacturing of Clinical-Grade Lentiviral VectorsSemantic proximity Read ↗

Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free MediaSemantic proximity Read ↗

Development of Stable Packaging and Producer Cell Lines for the Production of AAV VectorsSemantic proximity Read ↗

Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free mediaSemantic proximity Read ↗

Production of retroviral vectors in continuous high cell density cultureSemantic proximity Read ↗

Rapid Lentiviral Vector Producer Cell Line Generation Using a Single DNA ConstructSemantic proximity Read ↗

Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing PracticeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.