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Article

Non-integrating lentiviral vectors.

Current gene therapy - 1 Dec 2008

Sarkis Chamsy, Philippe Stéphanie, Mallet Jacques, Serguera Che

Abstract excerpt

Lentiviral vectors are among the most efficient gene transfer tools for dividing and non-dividing cells. However, insertional mutagenesis has been observed in clinical trials with oncoretroviral vectors and this has prompted detailed study of genotoxicty of all integrating vectors. For many applications, avoiding integration is the most straightforward approach to overcome this problem and is facilitated by the...

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PMID: 19075626
DOI: 10.2174/156652308786848012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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