Article
Stable gene transfer to muscle using non-integrating lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Nov 2007
Apolonia Luis, Waddington Simon N, Fernandes Carolina, Ward Natalie J, Bouma Gerben, Blundell Michael P, Thrasher Adrian J, Collins Mary K, Philpott Nicola J
Abstract excerpt
Human immunodeficiency virus (HIV)-based lentiviral vectors (LVs) hold immense promise for gene delivery applications because of their relatively large packaging capacity and their ability to infect a range of cell types. The genome of HIV non-specifically integrates into the host genome, and this promotes efficient, stable transgene expression in dividing cells. However, integration can also be problematic...
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