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Article

Conformation preorganization: effects of S20G mutation on the structure of human islet amyloid polypeptide segment.

The journal of physical chemistry. B - 21 May 2009

Xu Weixin, Jiang Ping, Mu Yuguang

Abstract excerpt

The missense mutation S20G in the human islet amyloid polypeptide (hIAPP) is supposed to be associated with the early onset of type II diabetes (T2DM) in Asian population. How such a single-point mutation induces variation of the conformation distribution and the amyloidogenic properties of hIAPP is still unknown. We studied the conformational ensembles of hIAPP segment 15-27 in both wild type and the S20G mutant...

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Source

Identifiers

PMID: 19402658
DOI: 10.1021/jp8106827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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