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Article

From annotated genomes to metabolic flux models and kinetic parameter fitting.

Omics : a journal of integrative biology - 1 Jan 2003

Segrè Daniel, Zucker Jeremy, Katz Jeremy, Lin Xiaoxia, D'haeseleer Patrik, Rindone Wayne P, Kharchenko Peter, Nguyen Dat H, Wright Matthew A, Church George M

Abstract excerpt

Significant advances in system-level modeling of cellular behavior can be achieved based on constraints derived from genomic information and on optimality hypotheses. For steady-state models of metabolic networks, mass conservation and reaction stoichiometry impose linear constraints on metabolic fluxes. Different objectives, such as maximization of growth rate or minimization of flux distance from a reference...

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PMID: 14583118
DOI: 10.1089/153623103322452413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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