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Article

Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant huntingtin.

Biochemical and biophysical research communications - 7 Dec 2012

Suzuki Mari, Nagai Yoshitaka, Wada Keiji, Koike Tatsuro

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal expansion of polyglutamine (polyQ) tract in huntingtin (htt) protein. Although altered calcium (Ca(2+)) homeostasis is suggested in HD, its molecular mechanisms have remained poorly understood despite their important role in the pathogenesis. In this study, we examined involvement of ryanodine receptor (RyR), an endoplasmic...

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Identifiers

PMID: 23131566
DOI: 10.1016/j.bbrc.2012.10.107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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