Article
Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6.
The Journal of biological chemistry - 1 Aug 2003
George Christopher H, Higgs Gemma V, Mackrill John J, Lai F Anthony
Abstract excerpt
Ca2+ homeostasis is a vital cellular control mechanism in which Ca2+ release from intracellular stores plays a central role. Ryanodine receptor (RyR)-mediated Ca2+ release is a key modulator of Ca2+ homeostasis, and the defective regulation of RyR is pathogenic. However, the molecular events unde...
Topics
- Adenosine Triphosphate
- Animals
- Apoptosis
- CHO Cells
- Calcium
- Calcium Channels
- Cell Death
- Cell Division
- Cresols
- Cricetinae
- Cytoplasm
- Gene Expression
- Heparin
- Humans
- Inositol 1,4,5-Trisphosphate Receptors
- Phenotype
- Receptors, Cytoplasmic and Nuclear
- Receptors, Purinergic P2