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Article

Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6.

The Journal of biological chemistry - 1 Aug 2003

George Christopher H, Higgs Gemma V, Mackrill John J, Lai F Anthony

Abstract excerpt

Ca2+ homeostasis is a vital cellular control mechanism in which Ca2+ release from intracellular stores plays a central role. Ryanodine receptor (RyR)-mediated Ca2+ release is a key modulator of Ca2+ homeostasis, and the defective regulation of RyR is pathogenic. However, the molecular events underlying RyR-mediated pathology remain undefined. Cells stably expressing recombinant human RyR2 (Chinese hamster ovary...

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PMID: 12754204
DOI: 10.1074/jbc.M212440200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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