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Article

The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein.

The Journal of biological chemistry - 21 Dec 2012

Donegan Rebecca K, Hill Shannon E, Turnage Katherine C, Orwig Susan D, Lieberman Raquel L

Abstract excerpt

Myocilin is a protein found in the trabecular meshwork extracellular matrix tissue of the eye that plays a role in regulating intraocular pressure. Both wild-type and certain myocilin variants containing mutations in the olfactomedin (OLF) domain are linked to the optic neuropathy glaucoma. Because calcium ions are important biological cofactors that play numerous roles in extracellular matrix proteins, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23129764
DOI: 10.1074/jbc.M112.408906
PMCID: PMC3527924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein.PMID 23129764Read ↗

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