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Article

Calcium dysregulation potentiates wild-type myocilin misfolding: implications for glaucoma pathogenesis.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Sept 2022

Saccuzzo Emily G, Martin Mackenzie D, Hill Kamisha R, Ma Minh Thu, Ku Yemo, Lieberman Raquel L

Abstract excerpt

Myocilin is secreted from trabecular meshwork cells to an eponymous extracellular matrix that is critical for maintaining intraocular pressure. Missense mutations found in the myocilin olfactomedin domain (OLF) lead to intracellular myocilin misfolding and are causative for the heritable form of early-onset glaucoma. The OLF domain contains a unique internal, hetero-dinuclear calcium site. Here, we tested the...

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Identifiers

PMID: 35831671
DOI: 10.1007/s00775-022-01946-3
PMCID: PMC10085244

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