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Article

The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder.

Biochemistry - 5 Jul 2011

Burns J Nicole, Turnage Katherine C, Walker Chandler A, Lieberman Raquel L

Abstract excerpt

Myocilin variants, localized to the olfactomedin (OLF) domain, are linked to early-onset, inherited forms of open-angle glaucoma. Disease-causing myocilin variants accumulate within trabecular meshwork cells instead of being secreted to the trabecular extracellular matrix of the eye. We hypothesize that, like in other diseases of protein misfolding, aggregation and downstream pathogenesis originate from the...

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Identifiers

PMID: 21612213
DOI: 10.1021/bi200231x
PMCID: PMC3128542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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