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Article

TMCO1 as an Endoplasmic Reticulum Calcium Load-Activated Channel: Mechanisms and Disease Implications.

Biomolecules - 20 Aug 2025

Wang Jingbo, Zhu Panpan, Li Zhuohang, Su Xiaohui, Qi Mingzhu, Zhou Aimin, Kong Xiangying

Abstract excerpt

Calcium ions (Ca2+) play a vital role in many biological processes. Transmembrane and coiled-coil domain 1 (TMCO1) has been characterized as an endoplasmic reticulum (ER) transmembrane protein in recent years. It keeps the cytoplasm and ER's Ca2+ homeostasis stable by acting as a novel calcium channel. Studies from different laboratories have revealed that the mutation or deficiency of TMCO1 is closely correlated...

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Identifiers

PMID: 40867644
DOI: 10.3390/biom15081200
PMCID: PMC12385146

Genes

TMCO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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