Article
The A/G allele of eIF3a rs3740556 predicts platinum-based chemotherapy resistance in lung cancer patients.
Lung cancer (Amsterdam, Netherlands) - 1 Jan 2013
Xu Xiaojing, Han Lifang, Yang Huaping, Duan Li, Zhou Boting, Zhao Yingchun, Qu Jian, Ma Rui, Zhou Honghao, Liu Zhaoqian
Abstract excerpt
eIF3a is the largest subunit of eukaryotic translation initiation factor 3, which has been suggested to affect tumor progression and activity of nucleotide excision repair pathway contributing to platinum resistance. The purpose of this study was to investigate possible mutations in promoter and exon regions of eIF3a gene and to assess whether eIF3a mutation status have prognostic and predictive significance in...
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