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ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer

14 Jul 2022

Abstract excerpt

Objective:This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress–related genesEIF2AK3/PERK,HSPA5/GRP78, andDDIT3/CHOP polymorphisms and the risk of lung cancer. Methods:Six single-nucleotide polymorphisms (SNPs) ofEIF2AK3,HSPA5, andDDIT3were genotyped in 620 cases and 620 controls using a MassARRAY platform. Results:The minor allele A of rs6750998 was a protective allele against...

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PMID: 35923704
DOI: 10.3389/fgene.2022.938787

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